Thursday, October 7, 2010

Kidney Disease Might Be Related To Insulin Disorder?

I've got 2 health problems: Gastric problems (Digestive problems) and Kidney Stones

Often the steps I take to address one often aggravate the other.

This article on alerted me to a new study pointing to insulin levels leading to kidney disease (and possibly renal failure)

Researchers most often attribute the disease to defects in the microvasculature of the kidneys as a result of high blood glucose levels, which are known to be toxic to a variety of cell types.

Diabetic kidney disease likely results from defective insulin signaling in the kidneys, contradicting long-standing suspicions, according to findings appearing online today (October 5) in Cell Metabolism.

Scientists have long attributed this type of kidney disease -- the leading cause of renal failure -- to high glucose levels in the blood and defects in the kidney microvasculature.

The study "suggests there's a direct effect of insulin" on epithelial cells in the kidney, "which is really a new idea," said nephrologist Thomas Coffman of Duke University School of Medicine, who was not involved in the research. "I'm sure it will be a highly cited paper."

Diabetes causes numerous health problems, including a form of kidney disease known as diabetic nephropathy (DN). DN is characterized by protein in the urine, enlarged kidneys, and abnormalities in the glomeruli, specialized capillaries where the urine filtration process begins, and other parts of the kidney.

Read more: Insulin is key to kidney disease - The Scientist - Magazine of the Life Sciences

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